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Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid

The two pathways activate different neuroendocrine axes

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NFE2L2 mRNA levels stay constant after exposure to DEM, indicating that Nrf2 is not positively regulating itself by expression of NFE2L2 mRNA

the reconstituted solution should be used promptly, ideally within 24 hours when no preservative is present, or within the timeframe specified by the study protocol