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Table 1 summarizes the characteristics of the included studies

Volvalerenic A is the primary metabolite among them

J Pharmacol Sci 95:1926 Petrovic I, Dobric I, Drvis P, Shejbal D, Brcic L, Boban Blagaic A et al (2006) An experimental model of prolonged esophagitis with sphincter failure in rat and therapeutic potential of gastric pentadecapeptide BPC 157

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The cells were then incubated with a secondary fluorescent-conjugated IgG (Alexa Fluor 488- IgG) (ab150077, Abcam) at room temperature for 1 h

NAD+ has been touted as the next great anti-aging treatment for fighting against age-associated diseases: During human aging, decrease of NAD + levels is associated with potentially reversible dysfunction in the liver, kidney, skeletal and cardiac muscle, endothelial cells, and neurons