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Increased TGF- signaling drives collagen deposition by hepatic stellate cells (HSC)/myofibroblasts

10.1073/pnas.76.1.56 429 MurogaY.TagawaH.HiragiY.UekiT.KataokaM.IzumiY.et al (1988)

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Our results identified the syringaldehyde like compounds such as phenol, 2,6-dimethoxy-4-(2-propenyl)- (compound 14) and ethanone, 1-(4-hydroxy-3,5-dimethoxyphenyl)- (compound 16), which were presented limited amount in secretome treatments but elevated when lignin was treated with H 2 O 2

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in catabolic research models suggest that IGF-1 LR3 may be more anabolic than IGF-1 because it appears to bind poorly to IGF-binding proteins