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It binds to estrogen receptors because it is structurally and functionally similar to estrogen to regulate estrogen-like actions

Proc Natl Acad Sci U S A 115:E1346E1355

8 , ra97 (2015)

Analogous to our observations, lung fibroblasts, but not macrophages, may upregulate IL-18 to control CD8 + T cell functions in COPD 46 , suggesting the immune-modulatory potential of fibroblasts in pulmonary disorders

This selective activity has made it a candidate of interest in obesity-related investigations

Also, NS workers exhibited greater social jet lag, shorter sleep, and disrupted diurnal patterns in immune biomarkers such as IL-6, lymphocytes, and T-helper cells, thereby reducing vaccine efficacy 119