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Although not reported for Mito-tempo other mitochondria-targeted SOD mimetics such as Mito-CP have been shown to reduce hydrogen peroxide and the subsequent hydrogen peroxide-induced inactivation of complex I and aconitase in endothelial cells (von Montfort et al., 2012)

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One animal study (Valdecantos et al., ADA 2024) showed obese rats given both compounds at sub-maximal doses lost more weight than either compound alone