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Furthermore, p-JNK leads to the activation of Bax and translocation to mitochondria to trigger the mitochondrial permeability transition (MPT) pore formation, along with collapsed ATP depletion and membrane potential, eventually causing DNA fragmentation and necrosis ( via upregulation of Gadd45

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These variations highlight that the in vitro physiological response of explants is influenced by multiple factors, including genotype, species, type and concentration of PGRs, explant source, and developmental stage of explant 53,54

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Epidermal growth factor receptor (EGFR) plays a key role in tumor evolution, proliferation and immune escape, and is one of the most important targets for the biotherapy of CRC