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Serine synthesis via PHGDH is essential for heme production in endothelial cells

Koizumi S, Okada Y, Miura S, et al

Similarly, CBD may interact with systems that have high levels of redundancy, or similar downstream processes (Mantovani 2018)

Indeed, accumulating evidence based on preclinical studies has identified ERK5 activation as a mediator of resistance to vemurafenib (BRAFi) and trametinib (MEKi) [54], and therefore, the combined targeting of ERK5 and ERK1/2 pathways results in better outcomes [55]

Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M , Brenner MK

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