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As tau becomes hyperphosphorylated, its capacity to support microtubule assembly and stability diminishes, resulting in increased levels of unbound tau that may aggregate into tangles (if not secreted or degraded in the lysosome) [107]

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Int J Med Mushrooms 13:3339 Abdullah N, Ismail S, Aminudin N, Adawiyah S, Beng L (2012) Evaluation of selected culinary medicinal mushrooms for antioxidant and ACE inhibitory activities

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Cells were stimulated with the formylated peptide fMLF, which signals through the plasma membrane receptor FRP1 and activates neutrophil secretion independently of endosomal activation or TLR9 function

One possible improvement (intrinsically offered by the time-domain approach since the arrival time of detected photons encodes the average investigated depth 9 ) could be the use of DTOF derived optical properties and/or magnetic resonance imaging derived information on the head geometry, which could both lead to defining optimal gate parameters on an individual basis