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In this case, pump speed is increased accordingly, which in turn increases mechanical stress and causes cellular damage as well as further activation of the coagulation hierarchy

Most importantly, targeting either GSH with the inhibitor BSO or Nrf2 through an siRNA approach or with the small molecule inhibitor ML385 sensitised resistant MRT cells to cisplatin-induced cell death suggesting that targeting the Nrf2/GSH antioxidant defence pathway may present a novel therapeutic avenue in the design of new treatment strategies for MRT and a means of overcoming chemoresistance

Oxygen in the headspace accelerates copper oxidation

10.1021/acsbiomaterials.0c00878 107 SuZ.BurchfieldJ

Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation

Chambers, L