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In a large longitudinal study of 1441 people with type 1 diabetes (T1D) in the Diabetes Control and Complications trial (DCCT), intensive insulin treatment reduced the risk of developing DPN by 60%, but a multifactorial approach, including managing hypertension, obesity, and hypertriglyceridemia, is necessary for those with type 2 diabetes (T2D) because of the diseases heterogeneous nature [41]

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For the research context the article is key for understanding why the amylin + GLP-1 combination makes mechanistic sense