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Moreover, IGFBP-2 is decreased in obese patients and thus increasing free IGF-1 [262]

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Some may require more frequent doses initially, especially when correcting a deficiency, before moving to a maintenance routine

In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)