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identified a non-inhibitory aptamer against the CRL2ZYG11B complex, employing it as an E3 warhead to construct dual-function ZATACs capable of degrading multiple targets, e.g., HaloTag ( Halo-ZATAC#T3 ) (Fig

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The results showed that a more extensive NT staining of centrilobular hepatocytes was observed in the WT+PCPA and KO groups (Figure 4F)