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However, fewer side effects does not automatically mean equally effective results. Label-guided slow titration already exists to balance both

During the early phase of nerve injury, infiltrated macrophages are predominated by pro-inflammatory (M1) phenotypes and, subsequently, transit to an intermediate phenotype characterized by the co-expression of pro-inflammatory (M1) and pro-regenerative (M2) macrophage markers or predominant pro-regenerative (M2) phenotype [7]

But update the diagnosis once the cause is confirmed.