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Activation of the pY397 autophosphorylation site of FAK promotes SRC binding, leading to the conformational activation of SRC, and, subsequently, a dual activated FAKSRC signalling complex (Mitra et al, 2005)

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We observed, while using cutoffs of E 10, that among the biological processes only the xenobiotic export, xenobiotic detoxification and export across the plasma membrane (Supplementary Table S3)

Indeed, in both studies, the highest frequency of TEAEs was in the normal function groups, possibly owing to the smaller sample sizes in the more severe impairment groups, or alternatively because participants with more serious health concerns, such as those with severe renal or hepatic impairment, may be less likely to notice or report mild or moderate TEAEs, as observed in populations with cancer [21]