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doi: 10.1016/j.gene.2020.144635 46 HuangGQuanLLiQZhouXHanMPengFet al

Resveratrol attenuates Trimethylamine-N-Oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota

doi: 10.1016/j.atherosclerosis.2008.08.039 54 HoseiniZ.SepahvandF.RashidiB.SahebkarA.MasoudifarA.MirzaeiH

One point of controversy that has been discussed since the seminal Framingham paper is that in the Framingham cohort up to 35% of CHD incidence occurred in subjects with a total cholesterol level of less than 5.2mmol/L ( 3mmol/L (116mg/dL), which is a sufficient exposure over the course of a 20-40 year period to contribute to atherosclerosis (discussed in LDL section below)

SGLT2i, by promoting urinary glucose excretion, ameliorate systemic IR and have been shown to reduce ectopic lipid deposition in muscle and the arterial wall, thereby addressing a key driver of the pathology in both tissues (141)

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