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10.1007/s00406-016-0731-4 Eur

GCL consists of Glutamate-Cysteine ligase Catalytic Subunit (GCLC) and Modifier Subunit (GCLM)

Therefore, when using metal chelators for diseases characterized by excess Cu intake, one must consider carefully their potential risk of neurotoxicity or loss of essential metals

MG-H1 formation in proteins leads to the substitution of charged hydrophilic arginine residue with hydrophobic uncharged MG-H1 residue

Moreover, rigorous kinetic analysis using model didpeptide and protein sulfenic acid shows that, by itself, 1,3-CPD reacts 20-fold slower than dimedone (ostensibly due to the stabilization of the carbanion in 1,3-CPD)

Nilius et al., 2001