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Moreover, the urinary excretion of isoprostane, a product of the nonenzymatic oxidation of arachidonic acid, and a marker of oxidative stress, was increased in vehicle-treated D 2 / mice and was almost completely normalized by etamicastat treatment (Fig

Ledo A, Arduini A, Asensi MA, Sastre J, Escrig R, Brugada M, et al

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

It posits that the gut microbiota and its metabolites impact ferroptosis in IBD by regulating intestinal barrier function, modulating inflammatory factors, and maintaining immune homeostasis

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