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Description

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281 By reducing macrophage-mediated inflammatory responses, GLP-1RAs have the potential to alleviate symptoms of OA, including pain and joint stiffness

The cell viability effects reported in vitro may be a possible reflection of the lack of cellular complexity in these models

The eicosanoids produced by 12-LOX are the activators of soluble functional acid cyclase, which can increase intracellular guanosine monophosphate (GMP) (Li et al., 1997b)

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