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Glutathione S-transferases (GSTs) catalyze the conjugation of GSH to a broad range of electrophilic compounds, including endogenous signaling molecules, reactive aldehydes such as 4-hydroxynonenal (4-HNE), and heavy metals 13,14

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It neutralizes free radicals, protects skin from environmental damage, and supports the skin's natural detoxification process

Concomitantly, systemic oxidative stress arising during liver damage can affect extrahepatic organs

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An early study reported a similarity between FSP1 and apoptosis-inducing factor mitochondria-associated 2, but this finding was disproved in a subsequent study [43]