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HIF stabilisers are emerging as an innovative therapeutic strategy for the treatment of IBD ( In vivo studies with 4-mercapto butyrate confirmed this pattern for systemic HIF stabilisation in mice (Ornelas et al., 2023)

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Among them, oxidative stress is considered the cornerstone where cyclophosphamide elicits massive generation of ROS coupled with downregulating activities of antioxidant enzymes alongside Nrf2 pathway