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10.1038/ncomms7774 128 Miroczuk-ChodakowskaI.WitkowskaA

In vitro biocompatibility and targeted elimination of senescent chondrocytes Though Cu is toxic to mammalian cells at high doses (causing jaundice, gastrointestinal ulcers, and liver and kidney damage) [49], appropriate doses of Cu can also promote mammalian cell differentiation and tissue repair [26, 50, 51]

If the drugs strength becomes unpredictable or its composition changes, it may not provide the intended treatment benefits and could lead to unexpected effects

Identification of MHC class ib ligands for stimulatory and inhibitory Ly49 receptors and induction of potent NK cell alloresponses in rats

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Song JX, An JR, Chen Q, Yang XY, Jia CL, Xu S, et al