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Description

Zhang Z, Sun J, Reynolds GP

Furthermore, as expected, our data indicate the existence of a trade-off between glutathione biosynthetic activity and cellular viability and fitness beyond a certain threshold, suggesting that an optimum should be aimed for in a possible strain engineering strategy

This deficiency promotes a vasospastic, prothrombotic, and inflammatory state in the vascular wall, which aligns with key Cerebral Small Vessel Disease mechanisms: hypoxia/ischemia and increased BBB permeability (Dobrynina et al., 2023)