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Docking substrates into the active site of the mutant Asn240Lys suffered from steric and entropic problems as Lys at position 240 oscillates (as evidenced by docking showing a wide range of different Lys240 positions), thereby obstructing access to the active site

A summary of these recommendations is listed in Table 5

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The earliest subjective improvements after B12 treatment occurred for paresthesia and balance, leading to full recovery [87]