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IDH is an enzyme to convert -KG into the oncogenic metabolite 2-HG

Intra-Brain Distribution After crossing the BBB via specific transporter, a drug, prodrug or nanocarrier can distribute from the brain ISF into the brain parenchymal cells via the same transporter expressed at the cellular membrane followed by the release of parent drug (in case of prodrugs and nanocarriers) or binding to the cell constituents, e.g

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It is worthwhile to mention that Hp lacking adenylylation of GS is also known for mixed acid fermentation pathways involving alternate electron acceptors and reduced TCA cycle activity 58

Am J Vet Res 1998;59:14314

Exploratory findings suggested that GHRH could potentially benefit individuals with initial MMSE scores of 27 or lower, indicating a therapeutic potential in adults with MCI [16]