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That is not nothing consistent effects across many animal models and delivery routes are a legitimate reason for scientific interest but it is a long way from demonstrated efficacy in humans

Neuroimaging , vol

Fatal disseminated Mycobacterium smegmatis infection in a child with inherited interferon gamma receptor deficiency

Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

And if I want the long term benefits, because if it's one of your patient, if it's one of your listener, who's, who's trying to get pregnant she, or he has to plan for A 30 day cycle, not a 15 minute