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If your health improves, your doctor may reduce this to once or twice a month

If you are uncomfortable with self-injecting, you can find a local clinic that will be happy to administer them for a small fee

Others less frequently are for deeper (and sometimes painful) intramuscular injections

The hallmark signs of B12 deficiency are neurological issues, including numbness, tingling, or pins and needles in hands and feet

Follow-up labs help show whether the injection schedule is working

(PMC) A separate metabolism-focused paper reviewing human trial history makes a similar point: early signals of weight loss were not consistently reproduced in later studies, particularly when intensive diet/exercise protocols were included