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pH of the medium should also be carefully selected to cater to the need as per the pH of the drug formulation, pH solubility profile of the active and also pH of the target membrane

For instance, the association of cationic lipids with EV membranes can enhance cellular uptake efficiency (Nakase and Futaki, 2015), while transferrin-conjugated superparamagnetic particles can endow EVs with magnetic responsiveness for imaging-guided therapy (Neubert and Glumm, 2016