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While AOD 9604 is considered to be a GRAS treatment

Polyamines are involved in cell division and proliferation, regulation of gene expression for cell survival, facilitation of DNA and protein synthesis, apoptosis and oxidative stress control, angiogenesis, and cell-to-cell communication (Lenis et al., 2017)

The effects were more pronounced with extended administration and earlier intervention

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Missing doses can reduce effectiveness and may require restarting the medication at a lower dose