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Thus, sorafenib is regarded as the first-line treatment in advanced HCC patients with a manageable adverse event (Llovet et al., 2008)

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Results from Platzbecker and colleagues showed a notable increase in erythropoiesis responses and a decrease in transfusion incidence in weeks 524 of darbepoetin alfa treatment compared with placebo in patients with LR-MDS, without differences among the groups in terms of the occurrence of thromboembolic events, and transformation to AML [250]

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