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Quarterly monitoring Every three months, assess: weight stability, appetite patterns, side effects, metabolic markers (if tracked), and lifestyle adherence

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Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regulation

erinaceus subentity and evaluated their hypoglycemic effects, revealing that these polysaccharides effectively reduced body weight and fasting blood glucose levels, improved glucose tolerance, mitigated hepatic lesions in streptozotocin-induced diabetic rats, and positively influenced glycogen synthesis via activation of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

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ROS also contribute to TNF-induced IL-6 expression and NF-B activation (Pearlstein et al., 2002)