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Learn more about cognitive health here: 6

Radiol 3:52-59, 2003

F., Clarke M

3 The role of ferroptosis in tumor microenvironment 3.1 Overview of ferroptosis in tumor microenvironment Ferroptotic cancer cells exert dual roles within the TME by releasing a variety of signals, which can both activate antitumor immune responses and promote the formation of an immunosuppressive TME

LIP-derived Fe 2+ participates in Fenton reactions, generating hydroxyl radical species that drive membrane lipid peroxidation and subsequent ferroptosis ( 2+ into the intracellular compartment ( The Fenton reaction, mediated by Fe 2+ and hydrogen peroxide, generates hydroxyl radicals that initiate non-enzymatic lipid peroxidation by abstracting hydrogen atoms from lipids, forming lipid radicals ( 2+ into less redox-active Fe 3+ is facilitated by ceruloplasmin (CP)