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One of the most commonly reported side effects is mild irritation at the injection site, which can manifest as redness, itching, or swelling

These findings underscore the importance of mitochondrial health in disc homeostasis and provide novel insights into precise strategies for treating age-related degenerative spinal diseases

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Acknowledgements We are thankful to the anonymous reviewers who helped improve this paper

The efficacy of ferroptosis inhibitors (e.g., GPX4 activators) or natural compounds in models of advanced DN (with established glomerular/tubulointerstitial damage) remains untestedwhether these interventions can reverse existing injury or only delay progression is unknown

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