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1963 Discovery of the enzyme carnitine palmitoyltransferase (CPT) 1973 First papers about patients with inborn errors in carnitine metabolism: muscular carnitine deficiency and CPT deficiency

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Biomarker-informed approaches incorporating inflammatory markers, cortisol levels, cognitive status, and symptom clustering may further refine patient selection and optimize therapeutic outcomes

Proc Natl Acad Sci U S A 93:1088710890 Forster A, Pannell R, Drynan LF, Codrington R, Daser A, Metzler M, Lobato MN, Rabbitts TH (2005) The invertor knock-in conditional chromosomal translocation mimic

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Metabolic Disorders Melatonin imbalance may affect metabolism, increasing the risk of diabetes, obesity, and lipid disorders