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It has been observed that repeated doses of DCA resulted in loss of GSTZ1-1 protein and activity, probably due to post-translationally modifications of the enzyme 85

Glutathione reductase in leaves of cowpea: cloning of two cDNAs, expression and enzymatic activity under progressive drought stress, desiccation and abscisic acid treatment

However, Phase 3 trials encountered setbacks due to incorrect dosages and regimens

Before GSSG assay, 100 L of filtrate were treated with 2 L of neat 2-vinylpyridine for 1 h on ice to block reduced GSH and then with 2 L of fourfold diluted triethanolamine solution