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This process resulted in the high-confidence assignment of 19 of the 31 fragments (Fig

Folinic acid therapy in treatment of dihydropteridine reductase deficiency

Larger, well-controlled clinical studies remain limited

Clear positive effect of Phe-reduced diet on lowering Phe levels was documented in the vast majority of patients

Injectable use in humans represents off-label experimental application with limited long-term human safety data specifically for injectable formulations

Daily intraperitoneal administration for 11 days reduced body weight gain, decreased white adipose tissue mass by approximately 35%, and reduced adipocyte size, while food intake between treated and control groups did not differ significantly