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By adopting the reverse translation of validated circuitry- relevant human endpoints approach [2], we provide convincing proof-of-concept for targeting OxS through antioxidant-based strategies in individuals with schizophrenia and underscore the importance of breaking the various vicious circles associated with OxS as means to prevent the propagation of processes that may precede the onset of disease

This model accurately risk stratifies 30-40% of indeterminate-risk individuals using commonly-available predictors, thus providing a scalable pathway to optimize tertiary care referrals

Adiponectin levels are diminished by sickness

mutant mouse with PS1M146V gene, APP/PS1

D.StrucchiC.LuisiM.CasarosaE.LanzoniC.BaraldiE.et al (2009)