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Access this article Similar content being viewed by others Abbreviations AGEP: Acute generalized exanthematous pustulosis ALT: Alanine aminotransferase APCs: Antigen-presenting cells AST: Aspartate aminotransferase CBZ: Carbamazepine CCR: CC-chemokine receptor COVID-19: Coronavirus disease 2019 CTL: Cytotoxic T cells CXCR: CXC chemokine receptor DiHS: Drug-induced hypersensitivity syndrome DRESS: Drug reaction with eosinophilia and systemic symptoms EBV: Epstein-Barr virus ESR: Erythrocyte sedimentation rate FasL: Fas ligand FADD: Fas-associated death domain protein HHV: Human herpesvirus HIV: Human immunodeficiency virus HLAs: Human leukocyte antigens HMGB-1: High-migration protein-1 Ig: Immunoglobulin IL: Interleukin IVIG: Intravenous immunoglobulin J-SCAR: Japanese Research Committee on Severe Cutaneous Adverse Reaction KC: Keratinocytes MCP: Monocyte chemotactic proteins MHC: Major histocompatibility complex NF-kB: Nuclear transcription factor-kappa B NK cells: Natural killer cells NSAIDs: Non-steroidal anti-inflammatory drugs TCR: T cell receptor TEN: Toxic epidermal necrolysis Th17: T helper type 17 TNF: Tumor necrosis factor RegiSCAR: European Registry of Serious Adverse Skin Reactions SCARs: Severe cutaneous adverse drug reactions SCORTEN: Score of Toxic Epidermal Necrolysis SJS: Stevens-Johnson syndrome References International drug monitoring: the role of national centres

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Acknowledgements The authors thank all those who contributed to this article, including Figdraw