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Specifically, parkin suppresses p53 promoter transactivation and reduces p53 mRNA levels through its Ring1 domain

Studies suggest that biotin deficiency, while rare, can lead to hair thinning and loss

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Therefore, PDT not only directly destroys the tumor cells in the irradiated area, but also activates the immune system of the body, recognizes and attacks distant tumor cells that are not directly affected by PDT, and achieves systemic anti-tumor immune effect

Rharass T, Lantow M, Gbankoto A, Weiss DG, Pankov D, Lucas S (2017) Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/-catenin/ROS signaling dependent manner