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Circulation 102:E73-86 Chibaudel B et al (2020) Association of bevacizumab plus oxaliplatin-based chemotherapy with disease-free survival and overall survival in patients with stage II colon cancer: a secondary analysis of the AVANT trial

To increase affinity toward CD36, researchers modified the linker region of the VHL-based PROTAC MZ1 by introducing cleavable polar groups (e.g., carboxyl, amino, Boc-protected groups)

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Figure 8 Eleven samples were available for the immunoblot assay ( Figure 9 )

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Notably, these genetic and epigenetic pathways interact, establishing cancer as a disease influenced by both intrinsic and extrinsic factors rather than isolated genetic events (Ramaiah et al