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Qu H, Ajuwon KM (2018) Adipose tissue-specific responses reveal an important role of lipogenesis during heat stress adaptation in pigs

Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1

In addition, ROS can contribute to mutagenesis of DNA by inducing strand breaks, purine oxidation, and protein-DNA cross-linking, and other ROS mediated alterations in chromatin structure may significantly affect gene expression (i.e