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This pathway begins with the accurate determination of the methylation status of key gene promoters (such as NIS and TSHR) in tumor tissues or circulating tumor DNA (ctDNA) using high-sensitivity techniques such as pyrosequencing or methylation-specific PCR [140, 141]

BNIP3 Heterodimerizes with Bcl-2/Bcl- XL and induces cell death independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

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A reduction in G i2 protein, but not G o and G s , expression has been described in cabergoline-resistant with respect to sensitive prolactinomas (53)