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Up to now, no adequate and well-controlled reproduction studies have been conducted in humans and animals to determine its effects on pregnant women.[24] However, there is also no reports of maternal or fetal harms with the ingestion of normal daily recommended amounts during pregnancy

However, for longer periods, its better to store them at lower temperatures

MOTS-c also regulates nuclear gene expression beyond AMPK, affecting glucose metabolism and oxidative capacity at the transcriptional level

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It directly stimulates anorexigenic POMC neurons and inhibits adjacent orexigenic NPY neurons in the ARC of the hypothalamus, thus promoting satiety, increasing energy expenditure, and resulting in weight loss (6)