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Understanding how the microbiome is involved in establishing, maintaining, and reversing obesity has been an active area of research 14,15,16 , and has included studies investigating links between the microbiome and obesity-related comorbidities such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) 17,18

The reconstituted product should be visually clear and colourless

Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state

Investigators would need to decide whether engaging in these activities would be part of the diet and exercise regimen detailed in the trial protocol or if such activities should be regarded as intercurrent events that need to be addressed in the statistical analysis

Plain-English summary: 5-Amino-1MQ and AOD-9604 both target fat without touching appetite

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