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The peptide also appears to have some direct effects on peripheral tissues beyond the central nervous system, including potential metabolic effects, cardiovascular influences, and immunomodulatory properties

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Taken in combination, MPH could induce apoptosis and neurodegeneration through its action on the CREB signalling pathway and oxidative stress generation through RAC1 and CAMK4

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Additionally, the lncRNA TUG1 negatively regulates the miR-29b-3p/CDK2 signaling pathway by binding to miR-29b-3p, resulting in the downregulation of CDK2 expression, which ultimately inhibits intestinal epithelial apoptosis

Microbiology (United Kingdom) (2016) 162(6):96678