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However, these variants did not affect the DNA repair activity of APE1, and they do not contribute to the risk of developing sALS (Hayward et al., 1999

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Drugs with similar barrier promoting properties may, therefore, be a useful strategy to improve the integrity of the intestinal epithelium and limit the development of gut-associated and extraintestinal inflammatory diseases (Smyth 2017)

Given the low therapeutic doses (0.10.5 mg/kg), rapid onset of action, sustained efficacy, and the feasibility of repeated administration without triggering hepatotoxicity, inflammation, or an immune response, hMUT mRNA-based therapy represents a versatile and promising option for MMA treatment [296]

Needed studies for Chemical Defense clinical indication including pharmacokinetics, safety, efficacy, pregnancy, breastfeeding, and review panel recommendations No data available at this time