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In contrast, the bound state exhibits a bimodal distribution with one peak overlapping the unbound state and a second, sharper peak, suggesting that cofactors binding induces an additional conformation (Supplementary Fig

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Evidence from preclinical and clinical studies Regular physical activity reshapes the systemic secretome, increasing circulating levels of myokines, adipokines, hepatokines, and neurotrophins, collectively termed exerkines, that exert endocrine effects on distal organs, including the retina