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LAG3 is an important inhibitory immune checkpoint that, by binding to MHC II molecules, suppresses T cell activation and proliferation ( + T cells into the tumor microenvironment, but also promotes T cell exhaustion by downregulating the secretion of key cytokines, such as IFN- ( Using the TIDE algorithm, our study predicted immunotherapy outcomes and found that patients in the high-risk group had higher overall TIDE and immune exclusion scores, with significantly lower response and benefit rates compared to the low-risk group

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FEBS letters , 581 (14), 2575-2579

The targeting process involves multiple steps from initial receptor binding through downstream metabolic effects

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Autoimmune Hepatitis Reactivation Reactivation Herpes Simplex Virus 1 and 2 of chronic HBV during or after chemotherapy Chemotherapy Osteosarcoma Immunosuppression Treatment goals: Reversal of liver Liver The liver is the largest gland in the human body