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Due to the ability of Al to be considered an oxidant compound, it is common the observation of a high generation of reactive oxygen species (ROS) in the cells

The results showed that the overexpression of ATP6AP1L gene with pcDNA3.1-GST DAF -ATP6AP1L and pcDNA3.1-GST CEAM7 -ATP6AP1L could significantly inhibit the proliferation of K-562 cells compared with the control cells transfected with empty vectors, pcDNA3.1-GST DAF, and pcDNA3.1-GST CEAM7 , respectively

Dynamic roles of p53mediated metabolic activities in ROSinduced stress responses

Nature 525 , 5661 (2015)