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Regulatory monitoring has recorded two serious adverse events in the FDAs FAERS database (2021, 2023) and one life-threatening event in the CAERS database

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Wu X, Hawse JR, Subramaniam M, Goetz MP, Ingle JN, Spelsberg TC (2009) The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells