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Malabsorption (inadequate intake of vitamin B12 in the intestine) Insufficient production of intrinsic factor (a protein that is produced in the gastric mucosa and is required for the absorption of vitamin C), Diseases in the terminal part of the ileum (part of the small intestine), eg

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No adverse metabolic effects observed

When caloric intake drops significantly, the resulting energy deficit can manifest as fatigue, weakness, or reduced exercise tolerance

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, et al

Specific findings worth noting: in a rat model of cysteamine-induced duodenal ulcers, BPC-157 administered intraperitoneally at 10 mcg/kg reduced ulcer area by approximately 75% compared to controls within 72 hours 4